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The Albumin-Dialysis-Principe with the OPAL-Kit:

The albumin-dialysis was developed in the early 90s. Two nephrologists University Hospital Rostock, Prof. Steffen Mitzner and Prof. Jan Stange, developed a method which had overcome the previous problems in the detoxification of the blood., especially in liver failure patients.

Behind it actually hides a simple solution. Whereas previously the blood was passed with its toxins directly through the adsorber surface (hemoperfusion) and thus besides immense clotting problems (complement activation, fibrinogen adsorption) and allergic reactions have been observed, the previous procedure was very unselective.

 

What could be more appropriate than the blood to liberate by a "natural" trick ago by toxin. This was achieved using a special membrane that allowed that molecules below 50,000 Dalton this can happen.

On the dialysate these toxins are then absorbed by clean, bondable human albumin and applied to a cleaning process in adsorbers.

This method is implemented by a combination of a liver dialysis module with a complementary kidney dialysis machine. Different combinations with the most popular devices from the fields HD and CRRT were used to.

After years of use, and some studies were many users think that it requires a further development. The clearance should be optimized and the structure handling are simplified.

These requirements have been implemented to date in the new "OPAL method".

 

OPAL Circuit

The Principe:

The new albumin dialysis system OPAL separates the patient's blood through a special blood-membrane from an albumin circuit which receives the toxins. The purification of albumin solution is via a LowFlux membrane (FX10) and a new adsorber (Cluster12). This carbon adsorber takes otherwise albumin-bound toxins to almost completely and thus purifies the albumin molecule. This may again pass through the blood-membrane and include new toxins.

The Blood-Membrane:

The special blood-membrane has the desired properties, to pass on the blood side of the toxins in the blood and the free albumin-bound toxin via the free diffusion of the dialysate with the relatively clean albumin.

After the albumin-bound toxins have left their blood-side carrier proteins and pass through the pores of the special membrane, are taken over and transported away from the albumin molecules in the circuit.

By adsorption the loaded albumin is regenerated in the circuit and can again take on toxins in the blood filter.

The "single pass" dialysis circuit right at the same time allowing the elimination of water-soluble substances and the maintenance and adjustment of the acid / base balance and electrolyte concentration.

Furthermore, can be controlled as in conventional hemofiltration procedures in intensive care units the volume balance of the patient here.

 

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Optimal Hi- and Low-Flux-Membrans
for Albumin-Dialysis

 

 


Membran-Processes

 

 

 

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